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Computational Chemist

Keywords / Skills : computational chemistry, CAD, structure-based and ligand-based molecular design techniques with a strong background in modern computational medicinal chemistry for small molecule optimization, structure-based drug discovery, cheminformatics and data

5 - 8 years
Posted: 2018-12-06

Industry
Bio Technology & Life Sciences
Function
Pharmaceutical/ Biotechnology
Role
Bio-Technology Research Scientist
Education
PhD
Stream:
Chemistry
Salary
2.50 - 2.80 lacs
Posted On
6th Dec 2018
Job Description
Within the IMI financed network of the European Lead Factory (ELF) and the recently established Drug Discovery Hub Dortmund (DDHD), Taros will now significantly extend its Drug Discovery business.


Job Objectives:
  • Work within a team of industry-seasoned molecule designers to deliver computational chemistry support to discovery programs and daily synthetic chemistry activities. 
  • Work alongside colleagues in drug discovery sciences in an interdisciplinary environment and actively contribute to projects at all stages of Drug Discovery & Development, including hit analyses and clustering, hit expansion methods, scaffold hopping, lead generation and lead optimization methods 
  • Excellent written and oral communication skills for writing project proposals, grant applications as well as project reports and presentations to collaborators and during internal team meetings 
  • Work in multidisciplinary project teams across multiple therapeutic areas and proactively guide medicinal chemistry design by timely application of the most appropriate computational methods and data analytics to influence molecular design and progress of the project 
  • Inspire the next generation of scientists by providing opportunities to develop their own skills and follow the science they are passionate about 
  • Coordination and supervision of PhD internships within the company 



Ideal Candidate Profile:
  • First degree in Chemistry or a related subject; PhD and optionally postdoctoral experience or equivalent experience in Computational Chemistry 
  • At least 3-5 years working experience in the area of computational chemistry, preferably in an industrial pharmaceutical R&D setting and cross site project work 
  • Experience and competence in structure-based and ligand-based molecular design techniques with a strong background in modern computational medicinal chemistry for small molecule optimization, structure-based drug discovery, cheminformatics and data analysis including visualization of results 
  • The innate ability, experience and confidence to manage and mentor a team on the application of computational methods to guide compound/library design 
  • The experience to take responsibility for identifying opportunities for future computational capability enhancements, including liaison with external software providers and academia as required 
  • A clear understanding of broader medicinal chemistry concepts and strategies with a track record of applying innovative solutions that have positively impacted project delivery 
  • A thorough understanding of how computational chemistry contributes to and influences drug discovery projects together with a good appreciation of other relevant disciplines, especially medicinal chemistry and structural biology 
  • Strong presentation and communication skills with high standards of written work 
  • Excellent time management skills, forward planning and delivery focus 
  • Self-outgoing, entrepreneurial and collaborative team player


About Company

Taros, an independent, privately owned contract research organization, based in Dortmund, Germany, has been serving the chemistry needs of pharmaceutical, chemical and biotech companies since its inception in 1999. More than 10.000 synthesis, research and process chemistry projects have successfully been delivered to the ever-growing global customer base.


Taros operates state-of-the-art lab facilities, employing a team of scientists (65% of whom hold post-graduate degrees in Chemistry) who are committed to supporting the diverse needs of its customers in efficient drug discovery, medicinal chemistry and classical synthetic chemistry. Taros’ scientists combine more than 140 years of industrial organic chemistry experience with over 60 years of active drug discovery experience from big pharmas and biotechs. Our chemists bear expertise across a broad range of therapeutic areas (oncology, respiratory, CNS, cardiovascular, inflammation, pain, metabolism and infectious) and in all small molecule target classes.


Taros has an experienced group of skilled chemists, who are involved in the design and synthesis of focused libraries of tens to hundreds of compounds, using parallel chemistry. To enhance the Dortmund-based compound library production capacity and to increase overall throughput of delivered compounds at the highest level of quality, Taros has invested into Agilent’s 1260 Infinity Prep Scale Purification and uHPLC-MS systems, a truly automated LC/MS-system supporting analytical and preparative purification workflows with minimal method development or scale-up work.
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